Disorganized histomorphology: Dentinogenic ghost cell tumor
نویسندگان
چکیده
Calcifying odontogenic cyst (COC) is a term used broadly to define lesions which were either cystic/solid in nature. However, a new term defining dentinogenic ghost cell tumor (DGCT), as its neoplastic counterpart, histopathologically showed the presence of dentinoid-like areas, ghost cells and ameloblastomatous-like odontogenic epithelium. This possesses a great challenge to an oral pathologist in diagnosing and differentiating it from solid multicystic ameloblastoma or COCs so as to ensure the biological behavior and pathogenesis behind its multifaceted nature. The author presents an exceptional case of DGCT, with special emphasis on its pathogenesis, occurring in an 80-year-old female with facial asymmetry and unique histopathology.
منابع مشابه
Dentinogenic Ghost Cell Tumor of the Peripheral Variant Mimicking Epulis
Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive odontogenic tumor regarded by many as a variant of calcifying odontogenic cyst. The peripheral variant of this clinical rarity appears as a well-circumscribed mass mimicking a nonspecific gingival enlargement. Microscopic appearance of odontogenic epithelium admixed with focal areas of dentinoid formation and sheets of ghost c...
متن کاملMetastatic Ghost Cell Odontogenic Carcinoma: Description of a Case and Search for Actionable Targets
Ghost cell odontogenic carcinoma (GCOC) is an exceedingly rare malignant tumor on the spectrum of already uncommon odontogenic or dentinogenic tumors. We describe here the case of metastatic GCOC in a patient with a history of recurrent dentinogenic ghost cell tumor of the mandible, now presenting with bilateral pleural effusions. We will discuss typical histopathologic and histochemical featur...
متن کاملIntraosseous and extraosseous variants of dentinogenic ghost cell tumor: two case reports
This paper aims to present both intraosseous and extraosseous variant of dentinogenic ghost cell tumor as well as a review of the literature. An 11-year old female patient presented a swelling and pain in the molar area of the mandible and a 15-year-old female patient reported a complaint of swelling in the right vestibular region of teeth 12 and 13(FDI 2-digit classification system). Microscop...
متن کاملCurrent Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst
Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differ...
متن کاملCalcifying Cystic Odontogenic Tumor with Ameloblastoma: A Case Report with Review of the Literature
controversies existed regarding the relationship between non-neoplastic cystic lesions and solid tumor masses. The so-called COC shows great diversity in the spectrum of clinical behavior and histopathological features, including cystic, solid (neoplastic), and aggressive (malignant) variants, because of which different categorization and nomenclature for the lesion have been proposed. In the 2...
متن کامل